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Contraindicated (one)pentobarbital will lower the extent or effect of cariprazine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is liable for the formation and elimination of cariprazine's Lively metabolites.pentobarbital will reduce the level or result of fentanyl by impacting hepatic/intestinal enzyme CYP3A4